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doi: 10.1159/000495775 11 DelgrangeEDaemsTVerhelstJAbsRMaiterD

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Preclinical studies and clinical trials evaluating CD38 inhibition are ongoing in patients with either solid tumors or hematological malignancies, including MM ( 2.4 CD38 enzyme activity and therapeutic antibodies: potential influence on refractoriness A crucial question is whether the binding of therapeutic CD38 antibodies interferes with the enzyme’s functional activity