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Abbreviations: cDC conventional dendritic cells COPD chronic obstructive pulmonary disease DC dendritic cells HDAC histone deacetylation LPS lipopolysaccharide MT metalloproteinases pDC plasmacytoid dendritic cells ROS reactive oxygen species Zn zinc ZnT zinc exporters ZIP zinc importers J.H.Y

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This system represents a highly effective and minimally immunogenic strategy for multimodal gouty arthritis therapy