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A link between obesity, PCOS, and dysbiosis, and the evidence of changes in microbiota composition in women with PCOS compared with healthy subjects are reported [16,77,89]

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The neurodegenerative cascade typically originates at the neuromuscular junction and distal axons, characterized by early synaptic dysfunction and axonal degeneration that progresses to neuronal death, ultimately causing neural transmission failure and motor impairment (Luan et al., 2024)