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Activation of NF-kappa B in virus-infected macrophages is dependent on mitochondrial oxidative stress and intracellular calcium: Downstream involvement of the kinases TGF-beta-activated kinase 1, mitogen-activated kinase/extracellular signal-regulated kinase kinase 1, and I kappa B kinase

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The first of these is an enzyme called superoxide dismutase (SOD), which catalyses the reaction between superoxide (O 2 - •) and 2 hydrogen ions (H + ) to produce hydrogen peroxide (H 2 O 2 )