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LC regulates the activity of several mitochondrial enzymes participating in mitochondrial metabolism [62,63,64]

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In response to epithelial injury that leads to the loss of CBCs, multiple differentiated epithelial lineages can replenish the CBC pool 5,6,7,8,9 by moving back along the crypt-villus axis toward the crypt base and dedifferentiating to reacquire stemness, thereby regenerating CBCs—a process collectively referred to as spatial plasticity 5,10,11