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In the fourth and last stage of B12 deficiency, clinical manifestations are experienced by the individual — including macrocytic anemia (a form of anemia in which red blood cells are larger than usual, hence the term “macro”) and, if left untreated, irreversible neurological damage

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This DA signaling mechanism in the BLA not only facilitates the normal sleep cycle but also contributes to the occurrence of cataplectic attacks in narcoleptics, illustrating its significance in both physiological and pathological aspects of sleep regulation ( Our analysis of dopamine and glutamate levels provides insights into the neuroprotective and cognitive effects of the treatments