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Cadmium accumulation in the brain causes behavioral alteration, which is exacerbated in rats fed with low protein diet [176]

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5.6 Lipoprotein(a): measurement nuance, biology beyond LDL, and therapeutic thresholds While HDL function assays are not standardized for routine care ( HDL-C concentration correlates inversely with risk, yet pharmacologic HDL-C raising has not consistently reduced events, suggesting that HDL function matters more than HDL quantity ( 5.7 Translating Lp(a) biology to therapy: modality trade-offs and implementation questions This framing also clarifies why some cardiometabolic interventions show broad cardiovascular benefit: they act on multiple nodes simultaneously—hepatic lipid flux, endothelial function, inflammatory tone, and thrombosis propensity (44–46, 54, 55)