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Perhaps more relevant, a murine model expressing a modest 50 % reduction in SOD1 protein ( Sod1 +/− ) elicits modest motor dysfunction and increases neuronal susceptibility to degeneration following axotomy [174] and other cellular stressors such as glutamate toxicity, [175] cerebral ischemia, [176] and aging

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Int J Fertil Womens Med 2000;45:236-40