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LO plays a crucial role in the synthesis of leukotrienes, mediators of numerous allergic and inflammatory conditions, and its expression is elevated in metabolic disease models, such as obese Zucker rats, where increased 5-LO and 12-LO in visceral adipose tissue is associated with higher leukotriene levels and pro-inflammatory cytokines (Reference Chakrabarti, Wen and Dobrian113)

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The gut microbiome is characterized by high diversity in every human, meaning that no standard or normal microbiome can be described [50]