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Chester D, Kathard R, Nortey J, Nellenbach K, Brown AC

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Preclinical studies have shown that guanfacine enhances prefrontal cortical (PFC) function by modulating cAMP–PKA–K⁺ signaling at post-synaptic alpha-2A receptors, thereby supporting and enhancing PFC neuronal firing and protecting dendritic spines from stress-related damage, and overall improvement in PFC functioning (30)