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In contrast, FBXL5-dependent IRPs degradation will decrease in iron-deficient cells, and thus, the interaction between IRPs and the IRE motif in the 5′-UTR of ferritin and FPN will inhibit the translation, while the binding of IRPs to an IRE at the 3′-UTR of TfR1 can protect mRNA against endonuclease cleavage [67]