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Besides CTCF motifs, the FL only, common and H373R only peaks displayed enrichment of OCT4-SOX2-TCF-NANOG motifs, which is in line with previous studies demonstrating cooperativity of these transcription factors with CTCF ( Fig.3F ) 47

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The promoter region of the GSTP1 gene is usually affected by methylation, and changes in methylation status suppress normal gene expression, which may lead to weakening or loss of its detoxification and antioxidant functions [220]

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