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Bio-based glutathione production: Microbial strategies and challenges - ScienceDirect

Comparing liver-specific CYP450 reductase knockout mice and wild-type mice, the inactivation of hepatic CYP450 could significantly increase TP bioavailability and levels in liver tissue, leading to increased hepatotoxicity (Xue et al., 2011)

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This confirms the anti-apoptotic effect is operating through the classical apoptotic pathway