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Intracellular ascorbate concentrations in the low millimolar range (much higher than that in plasma) seem to be necessary to support its role as an antioxidant [32] and as a cofactor for dioxygenase enzymes [33]

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High plasma TMAO concentrations were associated with increased incidence of all-cause mortality (14 studies for 16 cohorts enrolling 15,662 subjects, hazard ratio: 1.91