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Notably, host peroxisome proliferator-activated receptor gamma (PPAR-γ), a lipid-activated nuclear receptor, is upregulated in Mtb-infected MΦs via TLR2 signaling, promoting lipid droplet biogenesis and bacterial survival (195–197)

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So essentially what that means is you cannot do anything about the genes you were given in utero, but you can do something about the way they act