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Autoimmune Conditions Commonly Associated With Chronic Pain Many autoimmune and inflammatory disorders can contribute to persistent pain, including: Rheumatoid arthritis Psoriatic arthritis Lupus Hashimoto’s thyroiditis Sjogren’s syndrome Inflammatory bowel disease Small fiber neuropathy Fibromyalgia-like inflammatory syndromes Undifferentiated connective tissue disease The Role of Neuroinflammation in Chronic Pain One of the most important emerging concepts in pain medicine is the role of neuroinflammation