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The leading explanation for the high levels of oxidative stress biomarkers is an imbalance in selenoprotein antioxidant defense (Raymond et al., 2014), such as glutathione

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However, the presence of weak or moderate Trx activity was also detected in the airway epithelium and in alveolar macrophages of 6 healthy controls as well as in individuals with different histological diagnoses, specifically usual interstitial pneumonia (UIP) and desquamative interstitial pneumonia (DIP)