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In conclusion, laccaic acid A is a DNMT1 inhibitor with a DNA-competitive manner, which suggests that specifically substituted anthraquinones may be a useful scaffold for DNMTis ( Nanaomycin A ( 64 ) is an antibiotic that was recently reported to selectively inhibit DNMT3B with an IC 50 of 500 nM, while the activity of DNMT1 was not affected (Figure 10)