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The pursuit of precision medicine in this context involves not only elucidating the intricacies of glutamine-dependent pathways but also addressing the challenges posed by metabolic plasticity and the complex evolving tumor microenvironment

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Although this model cannot completely recapitulate the biological properties of human PH, the activation of oxidative stress 30, 31 , PAEC dysfunction 32 and inflammatory response activation can still provide some insights into the underlying pathogenesis of PH 30, 31