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Indeed, a PUFA-enriched WD containing 10% fish oil (with ω-3 and ω-6 PUFAs) evoked focal neutrophilic enteritis in male and female Gpx4 +/−IEC mice that was characterized by granuloma-like mucosal to submucosal accumulation of inflammatory cells and expression of the IL-8 homologue Cxcl1

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while in advanced phases the high biological value of the proteins and the high digestibility of the diet help to prevent the cardiac cachexy.