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is used as a traditional medicine in China

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The first identified agent was hydroquinone monobenzyl ether (monobenzone), which induces cell death without activating the caspase cascade or DNA fragmentation.98 Rhododendrol, another phenolic compound used in skin lightening treatments responsible for an outbreak of leukoderma in Japan, promotes cytotoxicity via a tyrosinase-dependent mechanism.99 Hair dyes have also been implicated in the appearance of leukoderma, and one of the main suspects is paraphenylenediamine