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3 The gut: the upstream hub of glucose and lipid metabolism abnormalities Recent shifts in dietary patterns have propelled research on the gut and metabolic diseases into a new stage ( Daniel ( This is primarily reflected in a reduction in protective bacteria: core probiotics such as Akkermansia muciniphila and Faecalibacterium prausnitzii ( Escherichia coli ( Furthermore, the imbalance of metabolically functional bacteria is equally critical: an abnormal abundance of bacteria responsible for converting primary to SBAs (secondary bile acids), such as Clostridium scindens ( Table 2 )