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GSH depletion induces upregulation of genes involved in detoxification and DNA synthesis To establish whether or not reduced GSH levels affects the expression of genes involved in oxidative detoxification and DNA synthesis, the mRNA levels of the superoxide dismutase ( sod) , glutaredoxin ( grx) and ribonucleotide reductase ( rnr) genes were determined in the pbggcs-ko2 , the pbgr - ko1 and the WT parasites

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[Google Scholar] 16.Dart RC, Paul IM, Bond GR, et al