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Furthermore, treatment with the zinc ionophore zinc pyrithione (ZnPTO, a membrane-permeable compound containing a zinc atom 51 ) without high glucose was sufficient to induce β-cell identity loss, manifested as a reduction in β cells and an increase in α cells and bi-hormonal INS + GCG + cells in human primary islets (Supplementary information, Fig

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10.1016/j.hoc.2009.01.008