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Thyroid–brain axis pathophysiology and neurological manifestations The major mechanistic routes linking thyroid dysfunction to neuropsychiatric manifestations are summarized in Figure 2, highlighting disrupted hormone transport/activation in the brain, neurotransmitter imbalance, oxidative stress–neuroinflammation, and blood–brain barrier vulnerability

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Cerella C, Coppola S, D’Alessio M, De Nicola M, Magrini A, Bergamaschi A et al