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Interestingly, neurons are thought to metabolize glucose primarily via the pentose phosphate pathway (PPP) to provide reducing equivalents required to maintain antioxidant defenses via the production of nicotinamide adenine dinucleotide phosphate (NADPH) (Figure 1.2 and 2.5) [39]

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successfully identified the pathogenic gene SAMD12 and the associated mutation (TTTCA)exp

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