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Chelator Deferiprone is known to redistribute iron and stimulate the expression of Frataxin, a mitochondrial iron chaperone

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As an illustrative example of the metabolic complexity of tumors, lung cancer cell lines are often glutamine dependent in vitro , but a recent study of K-RAS driven mouse lung tumors demonstrated that glucose but not glutamine was preferentially used to supply carbon to the TCA cycle, through the action of pyruvate carboxylase 190