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doi: 10.1089/ars.2023.0234 253 LiuYUrunoASaitoRMatsukawaNHishinumaESaigusaDet al

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Some scholars believe that APAP-induced acute liver failure is due to the nitrification of proteins 65 , this view has been supported by evidence showing that, while tocopherol supplementation can reduce APAP-induced lipid peroxidation (LPO), it does not attenuate APAP-induced liver injury, possibly due to its inability to affect peroxynitrite formation 66