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Cobalamin C defect should be considered in the differential diagnosis in adult patients with atypical hemolytic uremic syndromes, slow unexplained decline in renal function, idiopathic neuropathies, spinal cord degenerations, ataxias, unexplained or recurrent thrombosis, visual field defects, maculopathy, and optic disc atrophy (120)

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Spearman's correlation assessed relationships between neuroradiological features and altered Digit Symbol Coding (DSC), Trail Making Test (TMT), and MOCA adjusted scores (p 20 (ρ = +0.431), Left Deep CMBs (ρ = +0.363), Left Infratentorial CMBs (ρ = +0.348), Right Lobar CMBs (ρ = +0.338), and leukoaraiosis (ρ = +0.321)