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In naïve human CD4 + T-cells stimulated with anti-CD3/anti-CD28, dopamine (10 −8 –10 −7 M) increased the production of IL-5, IL-17, IL-1 β , and IL-6 and the dopamine-mediated changes in IL-5 and IL-17 were blocked by the presence of SCH23390 (D1-like receptor antagonist) (Nakano et al., 2011)