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L-carnitine — modest, shrinking effect A 2016 meta-analysis of 9 RCTs (n=911) found carnitine users lost about 1.33 kg more than controls, and a larger 2020 meta-analysis of 37 RCTs (n=2,292) found roughly 1.21 kg

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Clinical protocols recommend increasing doses every 7-14 days to allow your system to stabilize, rather than jumping to higher amounts too quickly