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Initial investigations shedding light on the importance of the gut microbiota in MS, constitute the surprising benefits of fecal microbial transplantation (FMT) in MS, and suggested as a therapeutic strategy ( + producing B cells to a specific gut microbial immune response, which constitutes an important gut-brain axis as they are recruited from the gut to the inflamed MS CNS during relapses and exert regulatory properties through IL-10 secretion ( 3 Systemic Lupus Erythematosus (SLE) 3.1 Pathogenesis Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease which can affect the joints, skin, nervous system, lungs, kidneys, and blood vessels