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Eligibility Criteria We included RCTs evaluating the efficacy and safety of glucagon receptor agonists, specifically survodutide, cotadutide, retatrutide, and mazdutide, in adult participants (≥ 18 years) diagnosed with obesity (Body Mass Index (BMI) ≥ 30 kg/m [2]), overweight (BMI ≥ 24 kg/m [2]), and/or T2DM