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We and other had shown in animal models and human subjects that inhibition of ACE improved diabetic peripheral neuropathy ( ® ) was the first representative of this class of drug and combines the dual action of sacubitril and valsartan ( Enalapril, α-lipoic acid & menhaden oil Based upon individual results as mono-therapies we tested the combination of enalapril, α-lipoic acid and menhaden (fish) oil on peripheral neuropathy ( Menhaden oil & salsalate Increasing consumption of omega-3 (n-3) polyunsaturated fatty acids, commonly found in marine mammals, (eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) through the diet or by supplements has been shown to improve cardiovascular disease ( Figure 4 ) ( Figure 5 ) ( Figure 4 Figure 5 Summary DPN is a disease with multiple etiologies thereby providing many potential targets for treatment

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, Angeles‐Valencia M., Morales‐González Á., et al