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ALL cells themselves can alter the endosteal and vascular compartments of the niche12 and induce apoptosis of osteoblast cells.17 The remodelled niche is dynamically transient and on exposure to chemotherapeutic agents, ALL cells can release CCL3 and cytokines TGF-β1 and GDF15, conferring chemoresistance by activating the TGF-β signaling pathway.12 It may be possible to overcome this resistance by disrupting the interactions between leukemia cells and the BM environment

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After 30 min of ischaemia, mice were sacrificed by cervical dislocation with the occlusion suture left in situ to prevent reperfusion