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These modifications may act downstream of core circadian regulators or be orchestrated by ubiquitin ligases and deubiquitinating enzymes that themselves may be under circadian control

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E2E1-I53-50A contained elevated levels of oligomannose at positions 430, 448, 476, and 623 possibly reflecting steric occlusion of these sites to mannosidase because of the trimeric organization of E2E1