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The Dangers of Skin Lightening with Glutathione IV: Safer Alternatives Explained

CFL might function as a redox sensor [208] and its dephosphorylation-dependent glutathionylation [209, 210] not only leads to a loss of its actin binding affinity, but also blocks its translocation to the mitochondria thereby preventing apoptosis induction

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They found that a small molecule drug, RSL3, inhibits an enzyme called glutathione peroxidase 4 (GPX4), which is overexpressed in papillary thyroid carcinoma specimens and prevents ferroptosis, a form of programmed cell death