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We then performed one-day or two-day knockdown using 115303 siRNA in the presence or absence of LPS and compared their knockdown efficiencies (with protocol described in the figure legend of Supplementary Fig

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Importantly, these phenotypes contrast with the non-inducible liver-specific Gclc KO mouse strain ( Gclc f/f Albumin-Cre), which develops liver failure and dies shortly after birth 30