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Fermented foods such as kefir further exemplify microbiota-targeted dietary strategies, enhancing beneficial bacterial populations and improving inflammatory balance, neurotransmission, and cognitive performance (Wouw et al., 2020) Similarly, seaweed supplementation may restore microbiota-driven amino acid metabolism and reinforce BBB integrity, contributing to motor and cognitive improvements in neurodegenerative contexts ( Though these findings by themselves require further studies to confirm their strength, particularly in human subjects and in a clinical context, they consolidate the concept that diet is a powerful upstream regulator of the gut-brain axis, when articulated together