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In a randomized, placebo-controlled intervention study with more than 900 older participants experiencing psychological distress, daily supplementation with folic acid (400 μg) and vitamin B 12 (100 μg) for two years did not reduce the occurrence of symptoms of depression despite significantly improving blood folate, vitamin B 12 , and homocysteine levels compared to placebo (109)

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Tablets just as effective Over-the-counter B12 tablets are a fraction of the cost of shots, and have been shown in a British-Canadian study to work just as well for most people, although some people with digestive conditions may have difficulty absorbing the vitamin in tablet form