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In this regard, alterations in hypothalamic growth hormone-releasing hormone (GHRH), one of the main stimulators of GH (reviewed in detail below), could affect the pituitary GH and consequently the GH/IGF axis

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However, anecdotal reports from online forums cited in a 2025 systematic review included anxiety and panic attacks, depression and anhedonia, insomnia, heart palpitations, fatigue and weakness, and loss of appetite