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The most potent compound found to be 40 (E)-N'-(4-chlorobenzylidene)-2-(3-(4-(4-methoxyphenyl)piperazin-1-yl)-6-oxopyridazin-1(6H)-yl)acetohydrazide with an IC 50 value of 0.17 µM followed by compound 41 (E)-N'-(4-chlorobenzylidene)-2-(3-morpholino-6-oxopyridazin-1(6H)-yl)acetohydrazide (IC 50 = 0.27 µM)