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Similarly, children and adolescents under chronic risperidone treatment showed a higher weight gain and, concurrently, changes in gut microbiota consisting in an altered ratio of Bacteroidetes: Firmicutes and an upregulation of metabolic pathways linked with weight gain, including alterations in butanoate, propanoate, fatty acid and tryptophan pathways [249]

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Pancreas-targeted LNPs like the vitamin-D formulation mentioned above could be highly valuable in this regard by concentrating expression in the pancreas