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Notably, histology-associated inflammation was observed in the lungs and kidneys, along with behavioral and molecular changes consistent with SARS-CoV-2–related brain dysfunction ( Human model for the vastus lateralis muscle tissue Human skeletal muscle samples were obtained from the vastus lateralis of individuals with a history of COVID-19, including patients with ongoing post-COVID symptoms (PCS), alongside healthy SARS-CoV-2–negative controls ( Human model for serum metabolomics Serum metabolomics analysis was performed using targeted quantitative LC–MS/MS and FIA–MS/MS profiling of 108 metabolites, following protocols established for long-COVID cohort studies (44)
