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acidophilus produces SCFAs such as acetate, which activates the SIGNR3 receptor, suppressing IL-6/STAT3 and RORฮณt pathways to inhibit Th17 differentiation while inducing Foxp3, IL-10, and TGF-ฮฒ to stabilize Tregs ( Figure 2 ) (37)
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2nd Tier Biologics : Tofacitinib (Janus Kinase inhibitor) (often labeled a โTargeted Biologicโ ) and other drugs in this subclass of medications have been found to be as effective as methotrexate, but their relatively higher incidence of โbiologicโ side effects for increased infections and cancer risk, as well as other side effects remain a cause for concern when their use is considered