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It plays a crucial role not only in protecting against oxidative stress but also in maintaining cellular homeostasis, regulating sulfur transport, conjugating metabolites, detoxifying xenobiotics, conferring antibiotic resistance, regulating enzyme activity, and modulating the expression of stress response genes (11)

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established a chemical cocktail of CHIR, A8301, and SAG (a Hedgehog signaling activator) combined with EGF, HGF and BMP4, which significantly promoted the expansion and stemness maintenance of HPCs (Pan et al., 2019)