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Other combinations of entero-pancreatic hormones including cagrisema (GLP-1/amylin RA) and the triple agonist retatrutide (GLP-1/GIP/glucagon RA) have also progressed to phase 3 trials as obesity treatments and early data suggests that may lead to even greater WL than tirzepatide

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Furthermore, a long heparan molecule could potentially bind to both of HGF I and II simultaneously, thus stabilizing the 2:2 c-MET/HGF complex