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Quantitative proteomics revealed that HY-10 induced degradation of several kinases—LIMK2, WEE1 and CDK7–cyclin H/MAT1 complex—all of which were further validated by western blot analysis (Fig

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Additionally, inhibition of CD38 in the AD mouse model restored NAD + levels, decreased mitochondrial ROS production and plaque depositions in the hippocampus and cortex, and improved cognitive abilities 158