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Factors such as age, comorbidities – including renal insufficiency, cardiovascular disease, diabetes, and obesity – and patient preferences can guide the choice and combination of therapies

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sensory neurons, specifically dorsal root ganglion (DRG) neurons, are located outside of the blood–nerve barrier, as do the peripheral sensory receptors, whereas motor neurons are located within the ventral horn of the spinal cord under the protection of the blood–brain barrier (Rondon et al., 2010

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