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This establishes a vicious cycle in which redox imbalance sustains both metabolic dysregulation and periodontal breakdown ( Peri-implant tissues appear particularly vulnerable in diabetic patients due to impaired angiogenesis, reduced antioxidant capacity, and delayed wound healing

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In this binge drinking rat model, ADH and ALDH activity were markedly decreased, whereas they were significantly recovered by GSH and GSH-rich YE (Fig